Quinobenzoxazine analogs and compositions

A compound having formula 2

• or a pharmaceutically acceptable salt or ester thereof;
• wherein A is NR1R2;
• Z is O;
• and
• U is NR1R2;
• B is a 5-6 membered aryl or heteroaryl;
• R1 is independently H or a C1-6 alkyl;
• and
• R2 is independently H, or a C1-10 alkyl or C2-10 alkenyl optionally containing one or more non-adjacent heteroatoms selected from N, O, and S, and optionally substituted with a substituted or unsubstituted aryl, heteroaryl, carbocyclic, or heterocyclic ring;
• or R2 is an optionally substituted cycloalkyl, heterocyclic ring, aryl or heteroaryl;
• or R1 and R2 together with N in NR1R2 may independently form an optionally substituted 5-6 membered ring containing N, and optionally O or S;
• R5 is a substituent at any position of B and is H, halo, cyano, azido, —CONHR1, OR2, or C1-6 alkyl or C2-6 alkenyl, where each C1-6 alkyl or C2-6 alkenyl is optionally substituted by halo, ═O or one or more heteroatoms;
• wherein each optionally substituted moiety is substituted with one or more halo, cyano, azido, acetyl, amido, OR2, NR1R2, carbamate, C1-10 alkyl, or C2-10 alkenyl, where each C1-6 alkyl or C2-6 alkenyl is optionally substituted by halo, ═O, aryl or one or more heteroatoms selected from N, O and S;
• or is substituted with an aryl, a carbocyclic or a heterocyclic ring.