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US 7,402,574 B2Granted
Antisense composition and method for treating cancer
AssigneeAVI BioPharma, Inc.
InventorsPatrick L. Iversen, Hemant K. Roy, Richard K. Bestwick
Life of this patent
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Abstract
A method and composition for treating colorectal cancer is disclosed. The method involves administering to a subject, a therapeutically effective amount of a morpholino antisense compound (i) having a nuclease-resistant backbone, (ii) capable of uptake by target cancer cells in the subject, (iii) containing between 10-40 nucleotide bases, and (iv) having a base sequence effective to hybridize to a region of processed or preprocessed human SNAIL RNA transcript.
Claims12
A method of treating colorectal cancer in a subject, comprising:
- administering to a subject a therapeutically effective amount of a composition of a morpholino antisense oligonucleotide, wherein the oligonucleotide is of about 10-40 bases in length, comprises a nuclease-resistant backbone and a targeting sequence which forms a heteroduplex with a target region of processed or preprocessed human SNAIL RNA transcript affecting expression of SNAIL protein, and inhibits expression of active SNAIL protein in target cancer cells.
Dependencies are inferred from the claim text.