Treatment of disease by inducing cell apoptosis
AssigneesThe Regents of the University of California, The United States of America as represented by the Department of Veterans Affairs, Office of the General Counsel (024)
InventorsMario Chojkier, Martina Buck
Life of this patent
Estimating the term…
Abstract
The present invention relates generally to the treatment and prevention of diseases characterized by excess cell proliferation and/or activation. In particular, the present invention provides compositions and methods to suppress the activation and/or proliferation of various cells. In preferred embodiments, the present invention provides compositions and methods to suppress the activation and/or proliferation of mesenchymally derived cells (including, but not limited to hepatic stellate cells), as well as cells with abnormal growth characteristics. In particularly preferred embodiments, the present invention provides compositions and methods to induce fibrosis.
Claims9
A method for inducing apoptosis comprising administering a composition to hepatic stellate cells, wherein said composition comprises N-acetyl-KAVD-C-aldehyde peptide (Ac-KAVD-CHO) consisting of residues 216-219 of SEQ ID NO:3 or N-acetyl-KKPA-C-aldehyde peptide (Ac-KKPA-CHO) consisting of residues 102-105 of SEQ ID NO:14.
Dependencies are inferred from the claim text.