Method of expressing long-chain prenyl diphosphate synthase

A transformant resulting from transformation of a host microorganism with an expression vector resulting from insertion of a DNA into a vector for expression,

• the DNA having the nucleotide sequence of SEQ ID NO:
• 3 and encoding a protein enabling or enhancing the activity of a protein encoded by the Schizosaccharomyces pombe DPS1 gene amplifiable with PCR primers of SEQ ID NOS:
• 13 and 14, the human DPS1 gene amplifiable with PCR primers of SEQ ID NOS:
• 15 and 16 and/or the mouse DPS1 gene amplifiable with PCR primers of SEQ ID NOS:
• 17 and 18 in the host microorganism;
• or
• the DNA having the nucleotide sequence isolated from the nucleotide sequence of SEQ ID NO:
• 3 by deletion, addition, insertion and/or substitution of one nucleotide thereof and encoding a protein enabling or enhancing the activity of a protein encoded by the Schizosaccharomyces pombe DPS1 gene amplifiable with PCR primers of SEQ ID NOS:
• 13 and 14, the human DPS1 gene amplifiable with PCR primers of SEQ ID NOS:
• 15 and 16 and/or the mouse DPS1 gene amplifiable with PCR primers of SEQ ID NOS:
• 17 and 18 in the host microorganism,
• the vector for expression being pSTV28 or pSTVK28-hDLP1,
• wherein the transformant is transformed with the Schizosaccharomyces pombe DPS1 gene amplifiable with PCR primers of SEQ ID NOS:
• 13 and 14, the human DPS1 gene amplifiable with PCR primers of SEQ ID NOS:
• 15 and 16 and/or the mouse DPS1 gene amplifiable with PCR primers of SEQ ID NOS:
• 17 and 18 further introduced therein.

A transformant resulting from transformation of Escherichia coil host microorganism with a DNA,

• the DNA having the nucleotide sequence of SEQ ID NO:
• 3 and encoding a protein enabling or enhancing the activity of a protein encoded by the Schizosaccharomyces pombe DPS1 gene amplifiable with PCR primers of SEQ ID NOS:
• 13 and 14, the human DPS1 gene amplifiable with PCR primers of SEQ ID NOS:
• 15 and 16 and/or the mouse DPS1 gene amplifiable with PCR primers of SEQ ID NOS:
• 17 and 18 in the host microorganism;
• or
• the DNA having the nucleotide sequence isolated from the nucleotide sequence of SEQ ID NO:
• 3 by deletion, addition, insertion and/or substitution of one nucleotide thereof and encoding a protein enabling or enhancing the activity of a protein encoded by the Schizosaccharomyces pombe DPS1 gene amplifiable with PCR primers of SEQ ID NOS:
• 13 and 14, the human DPS1 gene amplifiable with PCR primers of SEQ ID NOS:
• 15 and 16 and/or the mouse DPS1 gene amplifiable with PCR primers of SEQ ID NOS:
• 17 and 18 in the host microorganism,
• wherein the transformant is transformed with the Schizosaccharomyces pombe DPS1 gene amplifiable with PCR primers of SEQ ID NOS:
• 13 and 14, the human DPS1 gene amplifiable with PCR primers of SEQ ID NOS:
• 15 and 16 and/or the mouse DPS1 gene amplifiable with PCR primers of SEQ ID NOS:
• 17 and 18 further introduced therein.