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AssigneeMillennium Pharmaceuticals, Inc.
InventorsPaul D. Ponath, Douglas J. Ringler, S. Tarran Jones, Walter Newman, José Saldanha, Mary M. Bendig
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The present invention relates to isolated nucleic acids encoding humanized immunoglobulins having binding specificity for α4β7 integrin, isolated nucleic acids encoding a humanized immunoglobulin heavy chain and isolated nucleic acids encoding a humanized light chain having binding specificity for α4β7 integrin. The invention also relates to expression vectors and host cells comprising a nucleotide sequence which encodes a humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7. The invention further relates to methods of preparing a humanized immunoglobulin, humanized immunoglobulin heavy chain and humanized immunoglobulin light chain that has binding specificity for α4β7 integrin.
An isolated nucleic acid molecule encoding a humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7 integrin, wherein said humanized immunoglobulin or antigen-binding fragment thereof comprises a heavy chain and a light chain, said heavy chain comprising the variable region of SEQ ID NO:19, and said light chain comprising the variable region of SEQ ID NO:21.
An expression vector comprising a nucleotide sequence which encodes a humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7 integrin, wherein said humanized immunoglobulin or antigen-binding fragment thereof comprises a heavy chain and a light chain, said heavy chain comprising the variable region of SEQ ID NO:19, and said light chain comprising the variable region of SEQ ID NO:21.
An isolated nucleic acid molecule encoding a humanized immunoglobulin heavy chain or antigen-binding portion thereof, wherein said heavy chain or antigen-binding portion thereof comprises the variable region of SEQ ID NO:19.
An expression vector comprising a nucleotide sequence that encodes a humanized immunoglobulin heavy chain or antigen-binding portion thereof, wherein said heavy chain or antigen-binding portion thereof comprises the variable region of SEQ ID NO:19.
An isolated nucleic acid molecule encoding a humanized immunoglobulin light chain or antigen-binding portion thereof, wherein said light chain or antigen-binding portion thereof comprises the variable region of SEQ ID NO:21.
An expression vector encoding a humanized immunoglobulin light chain or antigen-binding portion thereof, wherein said light chain or antigen-binding portion thereof comprises the variable region of SEQ ID NO:21.
Dependencies are inferred from the claim text.