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US 7,402,388 B2Granted
Expression analysis of FKBP54 in assessing prostate cancer therapy
AssigneeWyeth
InventorsKimberly A. Gillis, Yixian Zhang
Life of this patent
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Abstract
The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating prostate cancer. FKBP markers are provided, wherein changes in the levels of expression of one or more of the FKBP markers is correlated with the presence of prostate cancer.
Claims25
A method of assessing the progress of a therapy for inhibiting prostate cancer in a human subject, the method comprising:
- obtaining a first biological sample from the subject, wherein the first sample is obtained prior to providing at least a portion of the therapy to the subject;
- obtaining a second biological sample from the subject, wherein the second sample is obtained from the subject following provision of the at least a portion of the therapy;
- determining the level of FKBP54 in the first and second samples;
- and
- comparing the level of FKBP54 in the samples, wherein a lower level of expression of FKBP54 in the second sample, relative to the first sample, is an indication of a positive therapeutic effect.
2 more elements
A method for determining the efficacy of androgen withdrawal treatment in a human prostate cancer patient, comprising:
- providing a first biological sample at a first time point from the patient and determining the expression level of FKBP54 in the first sample;
- providing a second biological sample at a second time point from the patient after the first time point, the second time point occurring after the patient begins androgen withdrawal treatment, and determining the expression level of FKBP54 in the second sample;
- comparing the expression level of FKBP54 in the first sample at the first time point with that in the second sample at the second time point,
- wherein an increase in the expression level of FKBP54 in the second sample compared with the first sample indicates that the androgen withdrawal treatment has become less effective over time, and wherein a decrease in the expression level of FKBP54 in the second sample compared to the first sample indicates that the androgen withdrawal treatment has a positive therapeutic effect.
1 more element
Dependencies are inferred from the claim text.