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AssigneeAlbert Einstein College of Medicine of Yeshiva University
InventorsEkaterina Dadachova, Joshua D. Nosanchuk, Arturo Casadevall
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This invention provides methods for imaging and/or treating a tumor in a subject which comprise administering to the subject an amount of a radiolabeled antibody effective to image and/or treat the tumor, where the radiolabeled antibody binds to a cellular component released by dying tumor cells. This invention also provides methods for imaging and/or treating melanin-containing melanomas in a subject which comprise administering to the subject an amount of a radiolabeled anti-melanin antibody effective to image and/or treat the melanoma. The invention also provides compositions and methods of making compositions comprising radiolabeled antibodies for imaging and treating tumors, including melanin-containing melanomas.
A method of treating a subject having a melanin-containing tumor which comprises administering to the subject a radiolabeled monoclonal antibody that specifically binds to melanin, wherein the radiolabeled monoclonal antibody is administered in a radiation dose of 1-1000 mCi and wherein administration of the radiolabeled monoclonal antibody to the subject inhibits growth of the melanin-containing tumor.
A method of imaging a melanin-containing tumor in a subject which comprises administering to the subject an amount of a radiolabeled monoclonal antibody effective to image the tumor, wherein the radiolabeled monoclonal antibody specifically binds to melanin and wherein the radiolabeled monoclonal antibody binds to melanin from a dead or dying melanin-containing tumor cell.
A method for treating a melanin-containing melanoma in a subject which comprises administering to the subject an amount of a radiolabeled monoclonal antibody effective to treat the melanoma, wherein the radiolabeled monoclonal antibody specifically binds to melanin.
A method for imaging a melanin-containing melanoma in a subject which comprises administering to the subject an amount of a radiolabeled monoclonal antibody effective to image the melanoma, wherein the radiolabeled monoclonal antibody specifically binds to melanin.
Dependencies are inferred from the claim text.