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US 7,402,303 B2Granted
Chemokine mutants in the treatment of multiple sclerosis
AssigneeLaboratoires Serono SA
InventorsAmanda Proudfoot, Timothy N. C. Wells, Marie Kosco-Vilbois
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Abstract
Mutants of CC chemokines, which contain at least two mutations in the cationic site of the 40's loop and which, relative to the wild-type molecule, have a reduced GAG-binding activity. In particular it has been found that such mutated chemokines are effective in the treatment of multiple sclerosis and/or demyelinating diseases. A triple mutant of RANTES is the compound showing the best results.
Claims2
A mutated human RANTES, consisting of the amino acid sequence of SEQ ID NO:2.
Dependencies are inferred from the claim text.