Chromatography column and method of operation
AssigneeMann Welding Company
InventorsWilliam H. Mann, Mickey Mann
Life of this patent
Estimating the term…
Abstract
A chromatography column is normally filled with a slurry of media for operation. A piston normally compacts the slurry in the column. The piston moves through a cavity in communication with both a slurry inlet and slurry ports which are in communication with the interior of the chromatography column. A controller receiving inputs from at least one of position sensors and a pressure sensor directs movement of the plunger in an operational step selected from the group of a selected movement and up to a selected pressure.
Claims20
A method for operating a chromatography column comprising:
- providing a cylinder with a plunger connected to a drive system, said plunger moveable within a cavity of the cylinder in an operational mode, said drive system having at least two drivers operably coupled to the plunger,
- position sensors respectively associated with the at least two drivers,
- a controller in communication with the position sensors, wherein said controller evaluates data relative to positions of the at least two drivers;
- providing at least one output for use in controlling operation of the at least two drivers with the controller to position the plunger up or down at least one of a predetermined distance and to at least one preset elevation relative to the cylinder while maintaining the plunger level.
A method of operating a chromatography column comprising:
- providing a cylinder with a plunger connected to a drive system, said plunger moveable within a cavity of the cylinder in an operational mode, said drive system having at least two drivers operably coupled to the plunger,
- at least two pressure sensors coupled respectively to the at least two drivers sensing pressures related to a resistance pressure exerted on the plunger by media within the cavity, and
- a controller in communication with the at least two pressure sensors, and evaluating data with the controller relative to the pressures provided by the at least two pressure sensors, and said controller providing at least one output for use in controlling operation of the at least two drivers while maintaining the plunger level.
Dependencies are inferred from the claim text.