Back to results
US 7,399,756 B2Granted
Organo-phosphorous compounds for activating gamma/delta T cells
AssigneeBioagency AG
InventorsHassan Jomaa, Matthias Eberl, Boran Altincicek, Martin Hintz, Oliver Wolf, Ann-Kristin Kollas, Armin Reichenberg, Jochen Wiesner
Life of this patent
Estimating the term…
Abstract
The present invention describes organophosphorus compounds of general formula (I) their preparation and their uses in the activation of gamma/delta T-cells, in the screening of GcpE and LytB enzyme inhibitors and in the prophylaxis and treatment of diseases in humans and animals.
Claims22
An isolated compound of general formula (III):
- in which R31 and R2, which cannot be present in the molecule simultaneously, are selected from the group consisting of OH, substituted or unsubstituted phosphate and substituted or unsubstituted pyrophosphate, a double bond is present between C1 and C2 if R31 is present in the molecule and a double bond is present between C0 and C1 if R2 is present in the molecule, R33 is selected from the group consisting of hydrogen, OH, substituted or unsubstituted phosphate and substituted or unsubstituted pyrophosphate, R34 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl having 1 to 26 carbon atoms, substituted or unsubstituted hydroxyalkyl having 1 to 26 carbon atoms, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted alkenyl having 1 to 26 carbon atoms, substituted or unsubstituted alkynyl having 1 to 26 carbon atoms, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclic radicals, substituted or unsubstituted phosphate, a silyl, a nucleoside, a deoxynucleoside, a nucleoside monophosphate, diphosphate or triphosphate, a cation of an organic or inorganic base, a cation of an organic or inorganic base wherein the metal is from main group I, II or III of the Periodic Table, ammonium, substituted ammonium and ammonium compounds derived from ethylenediamine or amino acids, X2 is either —OR6, R6 being defined analogously to R34, or can be
- R7 and R8 are independently selected from the group consisting of hydrogen, substituted or unsubstituted alkyl having 1 to 26 carbon atoms, substituted or unsubstituted hydroxyalkyl having 1 to 26 carbon atoms, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted alkenyl having 1 to 26 carbon atoms, substituted or unsubstituted alkynyl having 1 to 26 carbon atoms, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclic radicals, substituted or unsubstituted phosphate, a silyl, a nucleoside, a nucleoside monophosphate, diphosphate or triphosphate, a deoxynucleoside, a cation of an organic or inorganic base, a cation of an organic or inorganic base wherein the metal is from main group I, II or III of the Periodic Table, ammonium, substituted ammonium, ammonium compounds derived from ethylenediamine or amino acids, and OR34, and X1, X32 and X33, which can be identical or different, can be oxygen or a group
- Y and Z, which can be identical or different, being selected from the group consisting of H, OH, halogen, amino, C1-9-alkoxy and C1-9-alkylthio, or together forming an oxo group.
Dependencies are inferred from the claim text.