Glucuronyl C5-epimerase, DNA encoding the same and uses thereof

An isolated C5-epimerase polypeptide that has glucuronyl C5-epimerase activity that converts D-glucuronic acid to L-iduronic acid, or an enzymatically active fragment thereof that has said C5-epimerase activity, said polypeptide comprising an amino acid sequence at least 97% identical to sequence (n) below and at least 97% identical to at least one of sequences (a) to (m), or (o) below:

• (a) amino acids 1 to 118 of FIG. 3 (SEQ ID No. 2);
• (b) amino acids 1 to 119 of FIG. 3 (SEQ ID No. 2);
• (c) amino acids 1 to 120 of FIG. 3 (SEQ ID No. 2);
• (d) amino acids 1 to 121 of FIG. 3 (SEQ ID No. 2);
• (e) amino acids 119 to 618 of FIG. 3 (SEQ ID No. 2);
• (f) amino acids 120 to 618 of FIG. 3 (SEQ ID No. 2);
• (g) amino acids 121 to 618 of FIG. 3 (SEQ ID No. 2);
• (h) amino acids 122 to 618 of FIG. 3 (SEQ ID No. 2);
• (i) amino acids 34 to 147 of FIG. 3 (SEQ ID No. 2);
• (j) amino acids 35 to 154 of FIG. 3 (SEQ ID No. 2);
• (k) amino acids 34 to 154 of FIG. 3 (SEQ ID No. 2);
• (l) amino acids 1 to 154 of FIG. 3 (SEQ ID No. 2);
• (m) amino acids 155-618 of FIG. 3 (SEQ ID No. 2);
• and
• (n) amino acids 1-618 of FIG. 3 (SEQ ID No. 2);
• and
• (o) amino acids 34-618 of FIG. 3 (SEQ ID No. 2).