Multi-channel high-field asymmetric waveform ion mobility spectrometry
AssigneeAgilent Technologies, Inc.
InventorGangqiang Li
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Abstract
A multi-channel high field asymmetric waveform ion mobility spectrometer (FAIMS) is provided. The apparatus provides for substantially simultaneous FAIMS analysis of plurality of ions from a single sample. The apparatus has a analyzer region comprising a hollow electrode, a plurality of plate electrodes positioned parallel to and distanced from the hollow electrode, a contact for applying an high voltage asymmetric waveform to the hollow electrode and a plurality of contacts for applying a compensation voltage to the plurality of plate electrodes. A method for substantially simultaneous FAIMS analysis of plurality of ions from a single sample is also provided.
Claims22
An apparatus for separating ions, comprising:
- (a) an analyzer region comprising a hollow electrode and a plurality of plate electrodes, the hollow electrode having an external surface and a central region, the plate electrodes positioned parallel to and distanced from the external surface of the hollow electrode, wherein a channel is formed between each plate electrode of the plurality of plate electrodes and the hollow electrode;
- (b) a contact for applying an asymmetric waveform to the hollow electrode;
- and
- (c) a plurality of contacts for applying a compensation voltage to the plurality of plate electrodes wherein the compensation voltage is independently adjustable to each of the plurality of plate electrodes.
An apparatus for separating ions comprising a high field asymmetric waveform ion mobility spectrometer including:
- (a) an analyzer region comprising a hollow electrode and a plurality of plate electrodes, the hollow electrode having an internal surface surrounding a central region, the plate electrodes positioned in the central region, parallel to and distanced from the internal surface of the hollow electrode, wherein an ion channel is formed between each plate electrode of the plurality of plate electrodes and the hollow electrode;
- (b) a contact for applying an asymmetric waveform to the hollow electrode;
- and
- (c) a plurality of contacts for applying a compensation voltage to the plurality of plate electrodes wherein the compensation voltage is independently adjustable to each of the plurality of plate electrodes.
A method for separating ions comprising the steps of:
- (a) providing a plurality of ion species;
- (b) providing an analyzer including an analyzer region comprising a hollow electrode and a plurality of plate electrodes arranged parallel to and distanced from the hollow electrode, wherein a channel is formed between each plate electrode and the hollow electrode;
- c) providing a high voltage asymmetric waveform to the hollow electrode to generate a field in the plurality of channels between the hollow electrode and the plurality of plate of electrodes;
- d) providing a first compensation voltage to a first plate electrode of the plurality of plate electrodes and a second compensation voltage to a second plate electrode of the plurality of electrodes wherein the first compensation voltage is different than the second compensation voltage;
- e) setting the high voltage asymmetric waveform in order to effect a difference in net displacement between a first and a second ion species of the plurality of ion species in the field in the time of one cycle of the applied asymmetric waveform;
- and
- f) setting the compensation voltage of the first plate electrode of the plurality of plate electrodes to a determined value to support transmission of the first ion species through a first channel between the first plate electrode and the hollow electrode and setting the second compensation voltage to the second plate electrode to support transmission of a second ion species through a second channel between the second plate electrode and the hollow electrode.
Dependencies are inferred from the claim text.