Sulphonamide derivatives, their preparation and their therapeutic application

A compound having the formula (I)

• wherein
• Ar1 is
• phenyl optionally substituted with one or more substituents independently selected from the group consisting of:
• halogen, a (C1-C4) alkyl group, a (C1-C4) alkoxy group, a fluoro(C1-C4)alkyl group, a cyano group, —CO—NRaRb, and —NRaRb, Ra and Rb being, independently of each other, hydrogen or a (C1-C4) alkyl group;
• T is selected from
• —(CH2)n— where n=0, 1 or 2,
• where R2 is a hydroxyl group or a (C1-C4) alkyl group, or
• where R4 is a (C1-C4) alkyl group;
• Ar2 is phenyl optionally substituted with one or more substituents independently selected from:
• halogen, C1-C4) alkyl, (C1-C4) alkoxy, fluoro(C1-C4)alkyl, fluoro(C1-C4)alkoxy, and —NRcRd wherein Rc and Rd are, independently of each other, hydrogen or (C1-C4) alkyl,
• Ar3 is phenyl optionally substituted with one or more substituents independently selected from:
• halogen, (C1-C4) alkyl, (C1-C4) alkoxy, fluoro(C1-C4)alkyl, fluoro(C1-C4)alkoxy, nitro, hydroxyl, —NR5R6 where R5 and R6 are, independently of each other, hydrogen or (C1-C4) alkyl,
• R1 is a group of formula
• in which
• n=0, 1, 2 or 3
• R7 is hydrogen, (C1-C4) alkyl, fluorine or (C1-C4) alkoxy, —(CH2)m-aryl, where m=1 or 2 and aryl is a phenyl group optionally substituted with halogen, (C1-C4) alkyl or (C1-C4) alkoxy,
• R8 is hydrogen, fluorine or (C1-C4) alkyl, and
• R9 is
• —CO—NR12R13 where R12 and R13 are, independently of each other, hydrogen, (C1-C4) alkyl, optionally substituted with a —C≡N group,
• or, alternatively, R12 and R13 form, together with the nitrogen atom that bears them, a group
• or a salt, an enantiomer, a diastereoisomer, a rotamer, an atropoisomer or mixtures thereof.