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US 7,396,944 B2Granted
Thiophene derivatives, their manufacture and use as pharmaceutical agents
AssigneeHoffmann-La Roche Inc.
InventorsGeorg Fertig, Frank Herting, Matthias Koerner, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Ulrich Tibes
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Abstract
Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
Claims19
The (R)-enantiomers, (S)-enantiomers, or racemates of the compounds of formula I:
- wherein:
- (a) R1 is a (C1-C6)alkyl, which is optionally substituted one or more times by halogen;
- (b) X is phenylene or heteroarylene;
- and
- (c) Y is selected from the group consisting of:
- (1) a saturated (C3-C7)carbocyclic group;
- (2) a saturated heterocyclic group;
- (3) a heteroaryl group;
- and
- (4) a phenyl group, which is substituted one to three times by alkyl, halogen, —O-alkyl, —S(O)2-alkyl, —NH(alkyl) or —N(alkyl)2;
- wherein the alkyl groups are optionally substituted with one or more halogen atoms;
- and all pharmaceutically acceptable salts thereof.
9 more elements
Dependencies are inferred from the claim text.