Method for producing monatin
AssigneeAjinomoto Co., Inc.
InventorsKen-ichi Mori, Tadashi Takemoto
Life of this patent
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Abstract
By simultaneously carrying out an isomerization reaction at position 2 of monatin in different configurations at positions 2 and 4 in the presence of an aldehyde under a condition of pH 4 to 11 in a mixture solvent of water and an organic solvent, and the crystallization of monatin in the same configurations at positions 2 and 4 or a salt thereof, monatin useful as a sweetener, particularly optically active monatin can efficiently be produced.
Claims20
A method for producing monatin which has the same configurations at positions 2 and 4 or a salt thereof,
- said method comprising:
- isomerizing position 2 of monatin which has different configurations at positions 2 and 4 in a mixed solvent of water and an organic solvent comprising an alcohol in the presence of an aldehyde under a condition of pH 4 to 11 and simultaneously crystallizing said monatin which has the same configurations at positions 2 and 4 or salt thereof.
A method for producing (2R, 4R) monatin represented by formula (2) or a salt thereof:
- said method comprising:
- isomerizing position 2 of(2S, 4R) monatin represented by formula (1):
- in a mixture of(2S, 4R) monatin and (2R, 4R) monatin in a mixed solvent of water and an organic solvent comprising an alcohol in the presence of an aldehyde under a condition of pH 4 to 11 and simultaneously crystallizing said (2R, 4R) monatin of formula (2) or salt thereof.
A method for producing (2S, 4S) monatin represented by formula (4) or a salt thereof:
- said method comprising:
- isomerizing position 2 of(2R, 4S) monatin represented by formula (3):
- in a mixture of(2R, 4S) monatin and (2S, 4S) monatin in a mixed solvent of water and an organic solvent comprising an alcohol in the presence of an aldehyde under a condition of pH 4 to 11 and simultaneously crystallizing said (2S, 4S) monatin of formula (4) or salt thereof.
Dependencies are inferred from the claim text.