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US 7,396,931 B2Granted
Process for the preparation of amorphous form of a platelet aggregation inhibitor drug
AssigneeEgis Gyogyszergyar Rt.
InventorsPéter Kótay Nagy, Gyula Simig, József Barkóczy, Tamás Gregor, Béla Farkas, Györgyi Vereczkeyné Donáth, Kálmán Nagy, Gyuláné Körtvélyessy, Zsuzsanna Szent-Királlyi
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Abstract
The present invention relates to a new method of preparation of the polymorph form 1 of methyl (S)-(+)-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl-acetate hydrogensulfate of the formula (I)
Claims8
Process for the preparation of the amorphous form of methyl (S)-(+)-(2-clolophenyl-2(6,7-dihydro-4H-thieno [3,2-c]pyridine-5-yl-acetate hydrogen-sulfate of the formula
- which comprises,
- dissolving clopidogrel base in a first solvent,
- adding sulfuric acid,
- adding the obtained mixture containing clopidogrel hydrogensulfate to a second solvent to obtain a precipitate, and
- filtering precipitate,
- wherein the first solvent and the second solvent are present in one of the following combinations selected from the group consisting of:
- combination (i) acetone and diisopropyl ether;
- combination (ii) dichloromethane and diisopropyl ether;
- combination (iii) dichloromethane and cyclohexane;
- and
- combination (iv) dichloromethane and ethyl acetate.
8 more elements
Dependencies are inferred from the claim text.