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US 7,396,920 B2Granted
Tumour suppressor and uses thereof
AssigneeNovartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
InventorsBrian A Hemmings, Sauveur-Michel Maira
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Abstract
A human protein (designated Carboxy-terminal Modulating protein, CTMP) is described and is identified as having tumour suppressor properties. CTMP has been shown to interact with protein kinase B and inhibit protein kinase B activity, establishing its importance in the protein kinase B signalling pathway.
Claims5
An isolated nucleic acid comprising:
- (i) a nucleotide sequence as shown in SEQ ID NO:1 encoding carboxy terminal modulating protein, said protein having a protein kinase B binding activity, protein kinase B inhibiting activity, or tumor suppressive activity;
- (ii) a nucleotide sequence encoding carboxy-terminal modulating protein, said protein having a protein kinase B binding activity, protein kinase B inhibiting activity, or tumor suppressive activity, said nucleotide sequence differing from SEQ ID NO:1 by codon usage;
- (iii) a nucleotide sequence encoding a carboxy-terminal modulating protein homologue with at least 95% identity to SEQ ID NO:2, said protein homologue having a protein kinase B binding activity, protein kinase B inhibiting activity, or tumor suppressive activity, said nucleotide sequence differing from SEQ ID NO:1 by having at least one inserted, deleted or altered codon;
- or
- (iv) a nucleotide sequence fully complementary to the nucleotide sequences of (i), (ii) or (iii).
2 more elements
Dependencies are inferred from the claim text.