SARS nucleic acids, proteins, antibodies, and uses thereof
AssigneeUniversity of Massachusetts
InventorsDonna Ambrosino, Hector Hernandez, Thomas Greenough, Katherine Luzuriaga, Mohan Somasundaran, Gregory J. Babcock, William D. Thomas, Jr., John Sullivan
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Abstract
Codon-optimized nucleic acids, polypeptides, and antibodies are described herein.
Claims12
An isolated monoclonal antibody, or antigen binding portion thereof, that specifically binds to a SARS-CoV spike glycoprotein polypeptide (an S polypeptide), or fragment thereof, wherein the antibody, or antigen binding portion thereof, cross-competes for binding to the S polypeptide with a reference antibody, or antigen binding fragment thereof, that comprises:
- (a) a heavy chain variable region comprising the amino acid sequence shown in SEQ ID NO:13 or SEQ ID NO:149;
- and
- (b) a light chain variable region comprising the amino acid sequence shown in SEQ ID NO:14.
A monoclonal antibody, or antigen binding portion thereof, that binds to a SARS-CoV spike glycoprotein polypeptide (an S polypeptide), or fragment thereof, comprising:
- (a) a heavy chain variable region CDR1 comprising the amino acid sequence shown in SEQ ID NO:7;
- (b) a heavy chain variable region CDR2 comprising the amino acid sequence shown in SEQ ID NO:8;
- (c) a heavy chain variable region CDR3 comprising the amino acid sequence shown in SEQ ID NO:9;
- (d) a light chain variable region CDR1 comprising the amino acid sequence shown in SEQ ID NO:10;
- (e) a light chain variable region CDR2 comprising the amino acid sequence shown in SEQ ID NO:11;
- and
- (f) a light chain variable region CDR3 comprising the amino acid sequence shown in SEQ ID NO:12.
A monoclonal antibody, or antigen binding portion thereof, that binds to a SARS-CoV spike glycoprotein polypeptide (an S polypeptide), or fragment thereof, comprising:
- (a) a heavy chain variable region comprising the amino acid sequence shown in SEQ ID NO:13, SEQ ID NO:17 or SEQ ID NO:149;
- and
- (b) a light chain variable region comprising the amino acid sequence shown in SEQ ID NO:14.
An isolated antibody, or antigen binding portion thereof, that binds to an S polypeptide of SARS-CoV, wherein the heavy chain variable region comprises the amino acid sequence set forth in SEQ ID NO:13 or SEQ ID NO:149.
An isolated antibody, or antigen binding portion thereof, that binds to an S polypeptide of SARS-CoV, wherein the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:14.
Dependencies are inferred from the claim text.