Collagen production method

A method of producing collagen monomers comprising:

• (a) contacting Gram (+) bacteria belonging to the genus Bacillus in a fermenter with collagen-containing tissues, wherein the collagen-containing tissues are obtained from one or more of mammalian, aquatic, or avian animal sources;
• (b) allowing the bacteria to ferment the collagen-containing tissues at about 10% w/v to about 40% w/v in the fermenter;
• (c) solubilizing the fermented tissues at about 1% w/v to about 50% w/v in an acidic solution of about 0.5M acetic acid (pH 3.0) with pepsin provided at about 0.2% w/v to about 5% w/v at low temperatures;
• (d) adding salt to the acidic solution sufficient to precipitate collagen and keeping it undisturbed overnight;
• and
• (e) obtaining the precipitated collagen monomers,
• wherein the precipitated collagen product comprises collagen monomers weighing at least 10% of the weight of the total collagen in said collagen product.