Chimeric polypeptides containing chemokine domains
AssigneeGenetics Institute, Inc.
InventorsStephen H. Herrmann, Stephen L. Swanberg
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Abstract
This invention provides a chimeric DNA molecule comprising a sequence encoding a chemokine polypeptide covalently attached to a heterologous polypeptide, the encoded chimeric polypeptide, and uses thereof.
Claims18
A composition comprising a chimeric polypeptide, the chimeric polypeptide comprising at least one chemokine polypeptide covalently attached to at least one heterologous polypeptide, wherein the heterologous polypeptide is an Fc polypeptide, wherein the chemokine polypeptide comprises SEQ ID NO:1 from amino acid 22 to amino acid 328.
A chimeric polypeptide produced according to a process comprising:
- (a) growing a culture of a host cell in a suitable culture medium, wherein the host cell has been transformed with a polynucleotide comprising at least one expression control sequence, wherein the polynucleotide encodes a chimeric polypeptide, the chimeric polypeptide comprising at least one chemokine polypeptide covalently attached to at least one heterologous polypeptide, wherein the heterologous polypeptide is an Fc polypeptide and the chemokine polypeptide comprises SEQ ID NO:1 from amino acid 22 to amino acid 328, and
- (b) purifying said chimeric polypeptide from the culture.
Dependencies are inferred from the claim text.