Perturbed membrane-binding compounds
AssigneeNST Neurosurvival Technologies Ltd.
InventorsIlan Ziv, Anat Shievan, Sharon Ebner
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Abstract
The present invention provides uses of compounds that bind selectively to cells undergoing perturbations and alterations of their normal membrane organization, while binding to a lesser degree to cell having membranes of normal organization. These compounds are termed perturbed-membrane-binding compounds (PMBC). The PMBC group of compounds includes new compounds and also known compounds.
Claims4
A compound having the chemical formula
- wherein y is an integer of 2 to 6;
- z is an integer of 1 to 6;
- z is an integer of 1 to 6;
- T is selected from null, hydrogen and methyl;
- and R3 represents hydrogen or (C1-C6) alkyl.
A compound having the chemical formula
- and/or pharmaceutically acceptable salts and hydrates thereof.
A compound having the chemical formula
- and/or pharmaceutically acceptable salts and/or hydrates thereof, wherein R3 represents hydrogen or methyl.
A method for selectively binding a perturbed membrane-binding compound (PMBC) to a perturbed membrane in a cell(s), tissue(s) or cellular structure(s), comprising contacting a PMBC having the chemical formula
- and/or pharmaceutically acceptable salts and/or hydrates thereof,
- with a cell(s), tissue(s) or cellular structure(s) comprising a perturbed membrane(s) so that said PMBC binds to said perturbed membrane(s).
Dependencies are inferred from the claim text.