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US 7,396,857 B2Granted
Therapeutic combinations for the treatment or prevention of depression
AssigneeWyeth
InventorsJanet Jandura, Sharon Rosenzweig-Lipson
Life of this patent
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Abstract
Therapeutic combinations useful in the treatment or prevention of depression or other mood disorders, to pharmaceutical compositions containing said combinations, and to their use in the treatment or prophylaxis of depression or other mood disorders are provided. Such compounds are of formula I: or a pharmaceutically acceptable salt thereof, wherein each of R1, R2, R3, n, y, and Ar are as defined and described herein.
Claims16
A composition comprising:
- (a) a compound of formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- n is one or two;
- each of R2 and R3 is independently hydrogen, methyl, ethyl, 2-fluoroethyl, 2,2-difluoroethyl or cyclopropyl;
- each R1 is independently hydrogen, halogen, OH, lower alkyl, lower alkoxy, lower haloalkyl, lower haloalkoxy, or CN;
- Ar is thienyl, furyl, pyridyl, or phenyl, wherein Ar is optionally substituted with one or more Rx substituents;
- each Rx is independently selected from halogen, OH, lower alkyl, lower alkoxy, lower haloalkyl, lower haloalkoxy, or CN;
- and
- y is 0-3, and
- (b) an antidepressant.
7 more elements
Dependencies are inferred from the claim text.