Benzopyran analogs and their use for the treatment of glaucoma
AssigneeAlcon Inc.
InventorsMark R. Hellberg, Abdelmoula Namil
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Abstract
Novel benzopyran analogs are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.
Claims9
A compound represented by Formula I:
- wherein R1, R2, R3 are independently chosen from hydrogen or C1-3alkyl;
- R4 is chosen from R1 or OR1;
- R5 is chosen from hydrogen, F, Cl, OCONR1R2, OCOC1-3alkyl, or OR7;
- R6 is chosen from OR7, OCONR1R2, OCOC1-3alkyl;
- R7 is chosen from hydrogen, C2-4alkylCONR1R2, C2-4alkylNR1R2, C2-4alkylCO2H,
- C2-4alkylCO2C2-4alkyl, C1-3alkyl;
- wherein for R4,R5,R6 and R7, R1 and R2 are as defined above;
- and
- X and Y are independently chosen from C or O, provided that if one of X or Y are O, the other is C;
- or pharmaceutically acceptable salts of the compounds of Formula I.
A method for the treatment of glaucoma comprising administering to a patient a pharmaceutically effective amount of a composition comprising at least one compound of Formula I:
- wherein R1, R2, R3 are independently chosen from hydrogen or C1-3alkyl;
- R4 is chosen from R1 or OR1;
- R5 is chosen from hydrogen, F, Cl, OCONR1R2, OCOC1-3alkyl, or OR7;
- R6 is chosen from OR7, OCONR1R2, OCOC1-3alkyl;
- R7 is chosen from hydrogen, C2-4alkylCONR1R2, C2-4alkylNR1R2, C2-4alkylCO2H,
- C2-4alkylCO2C2-4alkyl, C1-3alkyl;
- wherein for R4, R5, R6 and R7, R1 and R2 are as defined above;
- and
- X and Y are independently chosen from C or O, provided that if one of X or Y are O, the other is C;
- or pharmaceutically acceptable salts thereof.
A method of controlling normal or elevated intraocular pressure comprising administering to a patient a pharmaceutically effective amount of a composition comprising at least one compound of Formula I:
- wherein R1, R2, R3 are independently chosen from hydrogen or C1-3alkyl;
- R4 is chosen from R1 or OR1;
- R5 is chosen from hydrogen, F, Cl, OCONR1R2, OCOC1-3alkyl, or OR7;
- R6 is chosen from OR7, OCONR1R2, OCOC1-3alkyl;
- R7 is chosen from hydrogen, C2-4alkylCONR1R2, C2-4alkylNR1R2, C2-4alkylCO2H,
- C2-4alkylCO2C2-4alkyl, C1-3alkyl;
- wherein for R4, R5, R6 and R7, R1 and R2 are as defined above;
- and
- X and Y are independently chosen from C or O, provided that if one of X or Y are O, the other is C;
- or pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.