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US 7,396,853 B2Granted
2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives
AssigneeHoffmann-La Roche Inc.
InventorsParichehr Malherbe, Raffaello Masciadri, Roger David Norcross, Eric Prinssen
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Abstract
The present invention relates to compounds of formula I: wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification and claims, which compounds are active on the GABAB receptor and are useful in the control or prevention of CNS illnesses, especially of illnesses and disorders comprising anxiety, depression, epilepsy, schizophrenia, and cognitive disorders.
Claims3
A compound of formula I-b:
- wherein
- R3 is t-butyl, 1,1 -dimethyipropyl or aryl;
- R4 is H;
- R5 is C1-6-alkyl or C1-6-haloalkyl;
- and
- R6 is H, hydroxy or C1-6-alkyl;
- or an optical isomer or pharmaceutically acceptable salt thereof.
4 more elements
A pharmaceutical composition comprising a therapeutically effective amount of a compound of formula I-b,
- wherein
- R3 is t-butyl, 1,1 -dimethyipropyl or aryl;
- R4is H;
- R5 is C1-6-alkyl or C1-6-haloalkyl;
- and
- R6 is H, hydroxy or C1-6-alkyl;
- or an optical isomer or pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.