Growth hormone secretagogues

A compound of the Formula I

• wherein:
• R1 is NHR10, (substituted or unsubstituted C1-C6alkyl)NHR10 or (unsubstituted or substituted C3-C8 cycloalkyl)NHR10;
• R10 is hydrogen, C1-C6alkyl, C1-C6alkyl(OH), C1-C6alkylidenyl(OH)R11, or an amino protecting group;
• R11 is C1-C6alkyl, C2-C6alkenyl, C1-C6alkyl(O)C1-C6alkyl, C(O)O—C1-C6alkyl, aryl, or C1-C6alkylaryl;
• R2 is hydrogen, C1-C6alkyl, aryl, or C1-C6alkylaryl;
• R4 is hydrogen, C1-C6alkyl, aryl, C1-C6alkylaryl, or C2-C6alkenyl;
• R5 is hydrogen, aryl, C1-C6alkylaryl, hydroxy, C1-C6alkoxy or, unsubstituted or substituted C1-C6alkyl;
• R6 and R7 are independently hydrogen, unsubstituted or substituted C1-C6alkyl, unsubstituted or substituted C2-C6alkenyl, or R6 and R7 together with the carbon atom to which they are attached form a carbocyclic ring of up to 8 atoms which is optionally partly unsaturated or a substituted C3-C8 cycloalkyl group which is optionally partly unsaturated;
• R8 is hydrogen, unsubstituted or substituted C1-C6alkyl, unsubstituted or substituted aryl, unsubstituted or substituted (C1-C6alkyl)C3-C8cycloalkyl, or unsubstituted or substituted C1-C6alkylaryl;
• Q is —S(O)2— or —C(O)—;
• m is a number selected from 1 or 2;
• R3 is substituted C1-C6alkylaryl, substituted C1-C6alkyl(O)—C1-C6alkylaryl, substituted C3-C8 cycloalkyl, substituted (C1-C6 alkyl)C3-C8 cycloalkyl, or aryl substituted by at least one —SO2CF3 group;
• and R9 is hydrogen, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C8cycloalkyl, C3-C8cycloalkenyl, cyano, optionally substituted aryl, optionally substituted —O-aryl, optionally substituted —N-aryl, optionally substituted —S-aryl, -aryl-aryl(K1)(K2), —O-aryl-aryl(K1)(K2), —N-aryl-aryl(K1)(K2), —S-aryl-aryl(K1)(K2), —O—C1-C6alkyl, or C1-C6alkylaryl, wherein K1 is halo or —CF3, and K2 is hydrogen, halo or —CF3 or K1 and K2 together form a methylenedioxy group;
• or
• R3 is optionally substituted aryl, C1-C6alkylaryl, C1-C6alkyl(O)—C1-C6alkylaryl, C3-C8 cycloalkyl, or (C1-C6 alkyl)C3-C8 cycloalkyl;
• and R9 is aryl substituted by at least one —SO2CF3 group, —O-aryl substituted by at least one —SO2CF3 group, —N-aryl substituted by at least one —SO2CF3 group, or —S-aryl substituted by at least one —SO2CF3 group;
• or a pharmaceutically acceptable salt thereof.