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US 7,396,840 B2Granted
Chemokine receptor binding heterocyclic compounds
AssigneeGenzyme Corporation
InventorsGary Bridger, Renato Skerlj, Al Kaller, Curtis Harwig, David Bogucki, Trevor R. Wilson, Jason Crawford, Ernest J. McEachern, Bern Atsma, Siqiao Nan, Yuanxi Zhou, Dominique Schols, Christopher Dennis Smith, Maria Rosaria Di Fluri
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Abstract
Tertiary amine compounds that bind chemokine receptors such as CXCR4 and CCR5 are disclosed.
Claims9
A compound of the formula
- and the pharmaceutically acceptable salts thereof wherein:
- each n is independently 0-2;
- each R is independently H or alkyl (1-6C);
- Ar is phenylene;
- each Y is independently optionally substituted pyrimidyl, imidazole, pyridyl, benzimidazole, or benzooxazole;
- and
- L2 is a covalent bond or a C1-6 alkylene,
- wherein said optional substituents are independently halogen, nitro, cyano, carboxylic acid, alkyl, alkenyl, cycloalkyl, hydroxyl, thiol, or amino, acyl;
- wherein the hydroxyl and thiol groups may be substituted by C1-10 alkyl or by C2-4 alkanoyl;
- and
- wherein an amino group may also be substituted once or twice with C1-10 alkyl, alkenyl or C2-4 alkanoyl.
8 more elements
Dependencies are inferred from the claim text.