Pharmaceutically active uridine esters
AssigneeTrommsdorff GmbH & Co. KG Arzneimittel
InventorRudy Susilo
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel uridine esters of the general formula wherein R represents a carboxylic acid residue, preferably a fatty acid residue and R′ represents hydrogen or a hydroxy group, their use as pharmaceutically active agents against a variety of diseases, methods for the preparation of said uridine esters and pharmaceutical compositions containing at least one uridine ester as active ingredient. The present invention relates also to a drug combination comprising free fatty acids and/or fatty acid esters and uridine, deoxyuridine, uridine monophosphate and/or deoxyuridine monophosphate, and to the use of such a drug combination.
Claims7
A method for treating at least one disease or condition selected from the group consisting of diabetes mellitus Type I and Type II, heavy metal poisoning, cerebral iseliemic disease, depression and stroke, in a mammal, said method comprises:
- administering to said mammal an amount of at least one compound of the general formula (I) and/or pharmaceutically acceptable salts thereof effective to treat the disease or condition:
- wherein
- R represents R″—COO;
- and
- R′ represents hydrogen or a hydroxy group;
- wherein R″ represents a monoenoic alkyl chain with 10 to 24 carbon atoms, a monoenoic branched alkyl chain with 10 to 24 carbon atoms, a polyenoic alkyl chain with 10 to 24 carbon atoms, a polyenoic branched alkyl chain with 10 to 24 carbon atoms, a branched or unbranched alkyl chain with 8 to 20 carbon atoms containing a carbocyclic or heterocyclic ring, a monoynoic alkyl chain with 10 to 24 carbon atoms, a monoynoic branched alkyl chain with 10 to 24 carbon atoms, a polyynoic alkyl chain with 10 to 24 carbon atoms, a polyynoic branched alkyl chain with 10 to 24 carbon atoms.
Dependencies are inferred from the claim text.