Immunogenic minicells and methods of use
AssigneeVaxiion Therapeutics, Inc.
InventorsRoger A. Sabbadini, Neil Berkley, Mark Surber
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Abstract
The disclosed invention relates to immunogenic minicells cells (anucleated) and their use to induce an immune response from a subject.
Claims25
A method of generating an immunogenic response in a subject comprising, introducing a minicell to a subject, wherein said minicell comprises a plasmid having an open reading frame encoding an antigen of interest, and a eukaryotic expression sequence operably linked to said open reading frame, such that said antigen of interest is expressed in the subject.
A method of generating an immunogenic response in a subject comprising, introducing a minicell to a subject, wherein said minicell comprises first and second open reading frames, encoding first and second antigens respectively, and a eukaryotic expression sequence operably linked to said first open reading frame and a prokaryotic expression sequence operably linked to said second open reading frame, such that said first antigen is expressed in the subject, and said second antigen is expressed in the minicell.
Dependencies are inferred from the claim text.