US 7,396,820 B2 · Anthelmintic formulations

Abstract

The present invention provides a method for preparing a pharmaceutical formulation containing ivermectin and a method and composition that can contain ivermectin plus hexahydropyrazinoisoquinolines, tetrahydropyrimidines and benzimidazoles or febantel. Examples of hexahydropyrazinoisoquinolines, tetrahydropyrimidines and benzimidazoles include praziquantel, pyrantel pamoate and fenbendazole, respectively. A pharmaceutical formulation is provided for use in the treatment of helminthiasis of mammals, and particularly tapeworm, hookworm, roundworm, whipworm and heartworm of domestic animals and farm animals. The present invention also provides a method of treating helminthiasis in mammals, which method comprises administering to the mammal in need thereof an anthelmintically effective amount of a pharmaceutical formulation of the invention.

Claims25

Dependent claims

A pharmaceutically acceptable solid anthelmintic formulation comprising a combination of

a first active ingredient comprising particles of an avermectin spray granulated with polyethylene glycol around the particles;
a second active ingredient comprising an anthelmintic pyrimidine;
a third active ingredient comprising a hexahydropyrazinoisoquinoline;
and
a fourth active ingredient comprising a benzimidazole or probenzimidazole,
wherein the polyethylene glycol coats the avermectin separating the avermectin from the second, third and fourth active ingredients.

3 more elements

Dependencies are inferred from the claim text.

Anthelmintic formulations

Life of this patent

Anthelmintic formulations

Life of this patent

Abstract

Claims25