Anthelmintic formulations
AssigneesVirbac, The Hartz Mountain Corporation
InventorsMichael Burke, Vinay Tripathi, Albert Ahn, Ian Cottrell
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Abstract
The present invention provides a method for preparing a pharmaceutical formulation containing ivermectin and a method and composition that can contain ivermectin plus hexahydropyrazinoisoquinolines and tetrahydropyrimidines. Examples of these include praziquantel and pyrantel. A pharmaceutical formulation is provided for use in the treatment of helminthiasis of mammals, and particularly tapeworm, hookworm, roundworm and heartworm of domestic animals and farm animals. The present invention also provides a method of treating helminthiasis in mammals, which method comprises administering to the mammal in need thereof an anthelmintically effective amount of a pharmaceutical formulation of the invention.
Claims26
A pharmaceutically acceptable solid anthelmintic formulation comprising
- a first active ingredient comprising particles of an avermectin spray granulated with polyethylene glycol around the particles;
- a second active ingredient comprising an anthelmintic pyrimidine;
- and
- a third active ingredient, comprising a hexahydropyrazinoisoquinoline,
- wherein the polyethylene glycol coats the avermectin separating the avermectin from the second and third active ingredients.
An anthelmintic formulation, which is in the form of a tablet, consisting essentially of
- an avermectin spray granulated with polyethylene glycol;
- a tetrahydropyrimidine;
- and
- a hexahydropyrazinoisoquinoline,
- the formulation in a condition that will remain active and in its tablet form for over one month, wherein the polyethylene glycol coats the avermectin separating the avermectin from the tetrahydropyrimidine and hexahydropyrazinoisoquinoline.
A method for forming an anthelmintic formulation comprising the steps of:
- preparing a combination of ivermectin and a polyethylene glycol carrier material, then spray granulating the combination to form granules, with the polyethylene glycol carrier material covering the ivermectin, the carrier material effective for isolating the ivermectin in the presence of other active anthelmintic ingredients;
- and
- combining the granules with an additional anthelmintic composition.
A method of forming an anthelmintic formulation comprising combining ivermectin with polyethylene glycol to form a combination and spray granulating the combination to form granules that effectively isolate the ivermectin and maintain the ivermectin stable for over one month;
- and
- combining the granules with an additional anthelmintic composition.
Dependencies are inferred from the claim text.