Sulfotransferase inhibitor
AssigneeSeikagaku Corporation
InventorsKoji Kimata, Hiroko Habuchi
Life of this patent
Estimating the term…
Abstract
The hexuronic acid derivative represented by the following formula 1 or a salt thereof is used as an active ingredient of a heparin/heparan sulfate sulfotransferase inhibitor. In the formula, each of R1, R2, and R3 independently represent(s) SO3− or H which may have a substituent, provided that at least one thereof represents SO3−; X represents OR4, SR4, N(R4)2, or C(R4)3, R4 independently represents H, alkyl, alkenyl, alkynyl, acyl, aryl, or aralkyl group; one of R5 and R6 represents COOH while the other represents H; and the wavy line represents α-glycosidic bond or β-glycosidic bond.
Claims4
A method of inhibiting a heparin/heparan sulfate sulfotransferase by contacting the heparin/heparan sulfate sulfotransferase with a hexuronic acid derivative represented by the following formula 1 or a salt thereof, wherein the heparin/heparan sulfate sulfotransferase has activity to transfer a sulfate group to a hydroxyl group at 6-position of a glucosamine residue or to a hydroxyl group at 2-position of a hexuronic acid residue in a heparin skeleton,
- wherein each of R1, R2, and R3 independently represent(s) SO3− or H, provided that at least one thereof represents SO3−;
- X represents OR4, R4 independently represents H, alkyl which may have a substituent selected from alkoxy group and acyloxy group, alkenyl, alkynyl, acyl, aryl, or aralkyl group;
- one of R5 and R6 represents COOH while the other represents H;
- and the wavy line represents α-glycosidic bond or β-glycosidic bond, wherein said acyl group is represented as —CO—R7 in which R7 represents a group selected from alkyl which may have a substituent selected from alkoxy group and acyloxy group, alkenyl, alkynyl, aryl, and aralkyl groups.
Dependencies are inferred from the claim text.