Application of Hsp70 proteins
OwnerGabriele Multhoffinventor
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Abstract
The invention relates to the use of Hsp70 protein or fragments thereof for the activation of NK-cells, pharmaceutical preparations, medical product or medical adjuvants containing a Hsp70 protein or fragments thereof or activated cells, method for the activation of NK-cells as well as medical use of the products obtained by the method of the invention.
Claims22
A method for the ex vivo activation of NK-cells, comprising:
- contacting NK cells in physiological suspension with an isolated and uncomplexed protein or protein fragment selected from the group consisting of a Hsp70 protein of SEQ ID NO.:
- 1 and a C-terminal fragment of Hsp70, wherein said fragment comprises amino acids 384-641 of SEQ ID NO.:
- 1, wherein said isolated protein or fragment, induce an immune response by NK cells, and further said response increases cytolytic activity of the NK cells or stimulates proliferation of the NK cells.
A method for in vivo activation of the immune system in a patient in need thereof comprising administering to said patient a pharmaceutically effective amount of an isolated and uncomplexed protein or protein fragment selected from the group consisting of a Hsp70 protein of SEQ ID NO.:
- 1 and a C-terminal fragment of Hsp70, wherein said fragment comprises amino acids 384-641 of SEQ ID NO.:
- 1, wherein said isolated protein or fragment induces an immune response by NK cells, and wherein said response increases cytolytic activity of the NK cells or stimulates proliferation of the NK cells.
Dependencies are inferred from the claim text.