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US 7,396,654 B2Granted
Neural proteins as biomarkers for traumatic brain injury
AssigneesUniversity of Florida Research Foundation, Inc., Banyan Biomarkers, Inc.
InventorsRonald Hayes, Kevin Ka-Wang Wang, Ming Chen Liu, Monika Oli
Life of this patent
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Abstract
The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
Claims7
A method of determining the presence of traumatic brain injury (TBI) in a subject, comprising:
- measuring the amount of ubiquitin C-terminal hydrolase L1 (UCH-L1) in a sample of cerebral spinal fluid (CSF) or blood from a subject at a time within and up to seven days after occurrence of a suspected TBI;
- and,
- comparing the amount of UCH-L1 in said sample with the amount of UCH-L1 in a respective sample from an uninjured subject
- wherein a higher amount of UCH-L1 in the subject sample relative to the amount in a CSF or blood sample from the uninjured subject is indicative of TBI in the subject suspected of having the TBI.
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Dependencies are inferred from the claim text.