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US 7,396,645 B1Granted
Cholestasis signature
AssigneeEntelos, Inc.
InventorsGeorges Natsoulis, Cecelia Pearson, Stuart Tugendreich, Michael Furness
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Abstract
The present invention provides methods and compositions for use in rapid test or prediction of the propensity of a test compound to induce cholestasis in a subject. The invention also includes a Cholestasis signature database as well as the method of deriving such database.
Claims6
A method for testing the propensity of a test compound to induce cholestasis in a test subject, the method comprising:
- a) administering an effective amount of the test compound to the test subject for a selected period of time;
- b) determining the change in expression level of each of a plurality of cholestasis indicator genes, wherein said plurality of indicator genes comprises the genes with GenBank accession numbers:
- AB010467 (SEQ ID NO:
- 1), X13295 (SEQ ID NO:
- 5), BF284899 (SEQ ID NO:
- 3), BF395678 (SEQ ID NO:
- 4), and AI411194 (SEQ ID NO:
- 2);
- c) determining the statistical significance of the change in expression level of each of said cholestasis indicator genes;
- d) assigning a probability of cholestasis induction due to said test compound if said plurality of said indicator genes exhibit a statistically significant change in expression level.
7 more elements
Dependencies are inferred from the claim text.