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AssigneeTeijin Limited
InventorsKazuyoshi Yamaoka, Kenichiro Takagi, Kenichiro Kataoka, Masanori Yamamoto, Toshihiro Chikanishi
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The present invention provides a method for screening a substance having a thermogenesis enhancing effect containing a compound having an effect activating PPAR δ, an agent containing the compound, and an agent having antidiabetic, antiobestic or visceral accumulated fat-lowering function. The present invention provides an agent containing a compound having an effect activating PPAR δ, which is a peroxisome proliferator activated receptor, and having effects which enhances nonshivering thermogenesis (nST), specifically enhances uncoupling respiration in mitochondria of cells in an adipose tissue or the like, or proton leak in inner membranes of mitochondria, and increases the amount of expression of UCP1, and provides an antidiabetic agent, an antiobestic gent and a visceral accumulated fat-lowering agent containing the compound. Further, the present invention provides a method for screening the compound by measuring a PPAR δ activating effect.
A method for screening for a compound that enhances thermogenesis by determining whether the compound activates PPAR δ, said method comprising:
A method for screening for a compound that enhances uncoupling respiration in mitochondria in mitochondria-containing cells, said method comprising:
A method for screening for a compound that enhances proton leak in inner membranes of mitochondria in mitochondria-containing cells, said method comprising:
A method for screening for a compound that increases the expression of UCP1 in mitochondria-containing cells, said method comprising:
A method for screening for a compound that enhances fatty acid β-oxidation in mitochondria-containing cells, said method comprising:
Dependencies are inferred from the claim text.