Heparin prodrugs and drug delivery stents formed therefrom
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsSyed Faiyaz Ahmed Hossainy, Ni Ding
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Abstract
A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
Claims15
A medical device comprising as a coating a prodrug, the prodrug comprising a drug, heparin, and a polymer,
- wherein the heparin is linked to the polymer;
- wherein the drug is linked to the heparin or the polymer;
- and
- wherein the polymer is poly(L-lysine-co-ethylene glycol) (PLL-co-PEG), poly(L-lysine-co-hyaluronic acid) (PLL-co-HA), poly(L-lysine-co-phosphoryl choline) (PLL-co-PC), poly(L-lysine-co-PVP), poly(ethylimine-co-ethylene glycol) (PEI-co-PEG), poly(ethylimine-co-hyaluronic acid) (PEI-co-HA), poly(ethylimine-co-phosphoryl choline) (PEI-co-PC), poly(ethylimine-co-vinylpyrrolidone) (PEI-co-PVP), poly(L-lysine-g-ethylene glycol) (PLL-g-PEG), poly(L-lysine-g-hyaluronic acid) (PLL-g-HA), poly(L-lysine-g-phosphoryl choline) (PLL-g-PC), poly(L-lysine-g-PVP), poly(ethylimine-g-ethylene glycol) (PEI-g-PEG), poly(ethylimine-g-hyaluronic acid) (PEI-g-HA), poly(ethylimine-g-phosphoryl choline) (PEI-g-PC), and poly(ethylimine-g-vinylpyrrolidone) (PEI-g-PVP).
A medical device comprising as a coating a prodrug, the prodrug comprising:
- a drug, heparin, and a polymer,
- wherein the heparin is linked to the polymer;
- and
- wherein the drug is linked to the heparin.
A medical device comprising as a coating a prodrug, the prodrug comprising a drug, heparin, and a polymer,
- wherein the heparin is linked to the polymer;
- wherein the drug is linked to the heparin or the polymer;
- and
- wherein the heparin is modified by a hydrophobic counter-ion.
Dependencies are inferred from the claim text.