Stent coatings with engineered drug release rate

A stent having a coating, the coating comprising a first region including a thermoplastic polyacrylate material and a therapeutic substance and a second region free from any therapeutic substances disposed on the surface of the stent and beneath the first region,

• wherein the polyacrylate material comprises poly(butyl methacrylate), and
• wherein the second region comprises a polymer selected from the group consisting of fluorinated polymers, poly(ethylene-co-vinyl alcohol), polydioxanone, poly(glycolic acid-co-trimethylene carbonate), polyphosphoester, polyphosphoester urethane, polycyanoacrylates, poly(trimethylene carbonate), poly(iminocarbonate), co-poly(ether-esters), polyalkylene oxalates, polmurethanes, silicones, polyisobutylene, ethylene-alphaolefin copolymers, vinyl halide polymers and copolymers, polyvinyl ethers, polyvinylidene chloride, polyacrylonitrile, polyvinyl ketones, polyvinyl aromatics, ethylene-methyl methacrylate copolymers, acrylonitrile-styrene copolymers, ABS resins, polyamides, alkyd resins, polyoxymethylenes, polyimides, polyethers, epoxy resins, polyurethanes, rayon, ravon-triacetate, fibrin, fibrinogen, cellulose, collagen, hyaluronic acid, cellulose acetate, cellulose butyrate, cellulose acetate butyrate, cellophane, cellulose nitrate, cellulose propionate, cellulose ethers, and carboxymethyl cellulose.

A stent having a coating, the coating comprising a first region including a thermoplastic polyacrylate material and a therapeutic substance and a second region free from any therapeutic substances disposed on the surface of the stent and beneath the first region, wherein the second region includes an ethylene vinyl alcohol copolymer.

A stent comprising a coating, wherein the coating comprises a first, second, and third layers disposed over one another wherein the second layer includes a thermoplastic polyacrylate material,

• wherein at least one of the layers includes a therapeutic substance,
• wherein the first layer is disposed on the outer surface of the stent, and
• wherein the third layer comprises a polymer selected from the group consisting of fluorinated polymers, poly(ethylene-co-vinyl alcohol), polydioxanone, poly(glycolic acid-co-trimethylene carbonate), polyphosphoester, polyphosphoester urethane, polycyanoacrylates, poly(trimethylene carbonate), poly(iminocarbonate), co-poly(ether-esters), polyalkylene oxalates, polyurethanes, silicones, polyisobutylene, ethylene-alphaolefin copolymers, vinyl halide polymers and copolymers, polyvinyl ethers, polyvinylidene chloride, polyacrylonitrile, polyvinyl ketones, polyvinyl aromatics, ethylene-methyl methacrylate copolymers, acrylonitrile-styrene copolymers, ABS resins, polyamides, alkyd resins, polyoxymethylenes, polyimides, polyethers, epoxy resins, polyurethanes, rayon, rayon-triacetate, fibrin, fibrinogen, cellulose, collagen, hyaluronic acid, cellulose acetate, cellulose butyrate, cellulose acetate butyrate, cellophane, cellulose nitrate, cellulose propionate, cellulose ethers, and carboxymethyl cellulose.