Cell delivery patch for myocardial tissue engineering
AssigneeThe Trustees of the University of Pennsylvania
InventorsAlexander Krupnick, Daniel Kreisel, Bruce R. Rosengard
Life of this patent
Estimating the term…
Abstract
A patch for cardiac tissue engineering includes a gel layer supported by an intermediate layer, which is attached to a reinforcement layer. These patches may be implanted in a heart to treat pediatric congenital malformations of the heart as well as adult ischemic myopathies. The gel layer may include cells such as, for example, stem cells; the intermediate layer may be biodegradable porous mesh and the reinforcement layer may be polytetrafluoroethylene. Included are methods for making patches according to the invention and for tissue engineering using patches of the invention.
Claims17
A cell delivery patch adapted for implantation in the heart of an animal, comprising:
- a collagen hydrogel layer having tissue cells for delivery and biologically active molecules disposed therein and/or thereon that enable said tissue cells to grow and/or differentiate;
- an intermediate layer that comprises a biodegradable porous mesh that forms a composite construct with said collagen hydrogel layer;
- and a reinforcement layer adjacent to said intermediate layer, said reinforcement layer comprising a material extending substantially over a cross-sectional dimension of said patch and having pliancy characteristics whereby it may withstand the forces of the heart during contraction so as to prevent ventricular dilation.
A cell delivery patch adapted for implantation in the heart of an animal, comprising:
- a collagen hydrogel layer having tissue cells for delivery and biologically active molecules disposed therein and/or thereon, said biologically active molecules enabling said tissue cells to grow and/or differentiate;
- an intermediate layer in contact-with said collagen hydrogel layer, said intermediate layer comprising a porous mesh that forms a composite construct with said collagen hydrogel layer;
- and
- a reinforcement layer adjacent to said intermediate layer, said reinforcement layer comprising at least one of non-biodegradable material and slowly biodegradable material, said reinforcement layer extending substantially over a cross-sectional dimension of said patch and having pliancy characteristics whereby said reinforcement layer may withstand the forces of the heart during contraction so as to prevent ventricular dilation.
Dependencies are inferred from the claim text.