Antibiotic polymers
AssigneeRutgers, The State University of New Jersey
InventorKathryn E. Uhrich
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Abstract
Polymers (i.e. polyesters, polyamides, polythioesters, polyanhydrides, or a mixture thereof) which degrade hydrolytically to provide a combination of a beta-lactam antibiotic (e.g., amoxicillin) and a beta-lactamase inhibitor (e.g., clavulanic acid) (or a pharmaceutically acceptable salt thereof) are provided. Methods of producing these polymers, intermediates useful for preparing these polymers, and methods of using these polymers to deliver a combination of a beta-lactam antibiotic and a beta-lactamase inhibitor (or a pharmaceutically acceptable salt thereof) to a host are also provided.
Claims22
A polymer comprising a backbone, wherein the polymer comprises (i) a group that will yield a beta-lactam antibiotic or a pharmaceutically acceptable salt thereof, and (ii) a group that will yield a beta-lactamase inhibitor selected from clavulanic acid, sulbactam, or tazobactamor or a pharmaceutically acceptable salt thereof, upon hydrolysis of the polymer;
- wherein the group that will yield a beta-lactam antibiotic or a pharmaceutically acceptable salt thereof, or the group that will yield the beta-lactamase inhibitor or a pharmaceutically acceptable salt thereof is chemically incorporated into the backbone of the polymer.
Dependencies are inferred from the claim text.