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US 7,396,465 B2Granted
Positively charged membrane
AssigneePall Corporation
InventorsXiaosong Wu, Chung-Jen Hou, Jayesh Dharia, Peter Konstantin, Yujing Yang
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AssigneePall Corporation
InventorsXiaosong Wu, Chung-Jen Hou, Jayesh Dharia, Peter Konstantin, Yujing Yang
Estimating the term…
The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
A positively charged microporous membrane comprising a porous substrate and a crosslinked coating, wherein the coating comprises a crosslinked polyamine that includes a polymer backbone and pendant cationic groups, said cationic groups including quaternary ammonium groups, wherein each pendant cationic group is directly linked to the backbone through a polar spacer group by a covalent bond.
Dependencies are inferred from the claim text.