Glutathione S-transferase sequence variants
AssigneeMayo Foundation for Medical Education and Research
InventorsRichard M. Weinshilboum, Baidehi Mukherjee, Linda L. Pelleymounter, Oreste Salavaggione, Eric D. Wieben
Life of this patent
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Abstract
Isolated GSTO2 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as GSTO2 allozymes. Methods for determining if a subject contains a GSTO2 sequence variant also are described.
Claims10
An isolated nucleic acid molecule consisting of a variant glutathione S-transferase omega 2 (GSTO2) nucleic acid sequence, wherein said variant GSTO2 nucleic acid sequence is selected from the group consisting of:
- a) at least fifteen contiguous nucleotides of SEQ ID NO:8, wherein said sequence includes nucleotide 121, 389, or 472 of SEQ ID NO:8, with the proviso that the nucleotide at position 121 is adenine, the nucleotide at position 389 is adenine, or the nucleotide at position 472 is adenine;
- and
- b) the full-length complement of a).
An isolated nucleic acid molecule consisting of a variant glutathione S-transferase omega 2 (GSTO2) nucleic acid and a label, wherein the sequence of said variant GSTO2 nucleic acid is selected from the group consisting of:
- a) at least fifteen contiguous nucleotides of SEQ ID NO:8, wherein said sequence includes nucleotide 121,389, or 472 of SEQ ID NO:8, with the proviso that the nucleotide at position 121 is adenine, the nucleotide at position 389 is adenine, or the nucleotide at position 472 is adenine;
- and
- b) the full-length complement of a).
Dependencies are inferred from the claim text.