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US 7,385,187 B2Granted
Multi-reflecting time-of-flight mass spectrometer and method of use
AssigneeLeco Corporation
InventorsAnatoli Verentchikov, Mikhail Yavor, Joel C. Mitchell, Viatcheslav Arteav
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Abstract
A multiple reflecting time-of-flight mass spectrometer (MR-TOF MS) and method of analysis are disclosed. The flight path of ions is folded along a trajectory by electrostatic mirrors. The longer flight path provides higher resolution while maintaining a moderate instrument size.
Claims59
A multi-reflecting time-of-flight mass spectrometer (MR-TOF MS) comprising:
- an ion source;
- an ion receiver downstream from said ion source;
- at least one ion mirror assembly intermediate said ion source and said ion receiver and elongated in a shift direction for improving sensitivity and resolution of the MR-TOF MS;
- a drift space intermediate said ion mirror assembly;
- and
- a lens assembly disposed within said drift space along said at least one shift direction and with a period in said shift direction corresponding to ion shift per integer number of ion reflections,
- said ion source, ion receiver, ion mirror assembly and said drift space arranged to provide a folded ion path between said ion source and said ion receiver composed of at least one reflection by said ion mirror assembly for separating ions in time according to their mass-to-charge ratio (m/z) so that a flight time of the ions is substantially independent of ion energy.
4 more elements
A multi-reflecting time-of-flight mass spectrometer (MR-TOF MS) comprising:
- an ion source;
- an ion receiver downstream from said ion source;
- at least one ion mirror assembly intermediate said ion source and said ion receiver and elongated in a shift direction for improving sensitivity and resolution of the MR-TOF MS;
- and
- a drift space intermediate said ion mirror assembly,
- said ion source, ion receiver, ion mirror assembly and said drift space arranged to provide a folded ion path between said ion source and said ion receiver composed of at least one reflection by said ion mirror assembly for separating ions in time according to their mass-to-charge ratio (m/z) so that a flight time of the ions is substantially independent of ion energy,
- wherein said ion mirror assembly comprises a plurality of electrodes shaped and spaced relative to one another to provide a spatial ion focusing and time-of-flight focusing of ions substantially independent of ion energy and on ion position in a plane transverse to said ion path.
4 more elements
The MR-TOF MS as defined inclaim 1, wherein said drift space comprises an ion deflector connected to one of a DC voltage supply and a pulsed voltage supply.
A tandem multi-reflecting time-of-flight mass spectrometer (MR-TOF MS-MS) apparatus comprising:
- a first multi-reflecting time-of-flight mass spectrometer (MR-TOF MS) for separating parent ions;
- a fragmentation cell attached to said first MR-TOF MS for receiving said parent ions;
- and
- a second MR-TOF MS attached to said fragmentation cell for mass analysis of daughter ions exiting said fragmentation cell, wherein at least one of said MR-TOF MS comprises at least two grid-less and parallel ion mirrors separated by drift space and substantially elongated in one shift-direction,
- wherein at least one of said first and second MR-TOF MS comprises:
- an ion source;
- an ion receiver downstream from said ion source;
- at least one ion mirror assembly intermediate said ion source and said ion receiver and elongated in a shift direction for improving sensitivity and resolution of the MR-TOF MS;
- a drift space intermediate said ion mirror assembly;
- and
- a lens assembly disposed within said drift space along said at least one shift direction and with a period in said shift direction corresponding to ion shift per integer number of ion reflections,
- said ion source, ion receiver, ion mirror assembly and said drift space arranged to provide a folded ion path between said ion source and
- said ion receiver composed of at least one reflection by said ion mirror assembly for separating ions in time according to their mass-to-charge ratio (m/z) so that a flight time of the ions is substantially independent of ion energy.
10 more elements
A multi-reflecting time-of-flight mass spectrometer (MR-TOF MS-MS) apparatus comprising:
- a multi-reflecting time-of-flight mass spectrometer (MR-TOF MS);
- and
- a fragmentation cell connected to said MR-TOF MS and configured to revert ions within said MR-TOF MS to employ the same MR-TOF analyzer for analysis of both parent ions and fragment ions, wherein said MR-TOF MS comprises an assembly of two grid-less and parallel ion mirrors separated by drift space and substantially elongated in one shift-direction,
- wherein said MR-TOF MS comprises:
- an ion source;
- an ion receiver downstream from said ion source;
- at least one ion mirror assembly intermediate said ion source and said ion receiver and elongated in a shift direction for improving sensitivity and resolution of the MR-TOF MS;
- a drift space intermediate said ion mirror assembly;
- and
- a lens assembly disposed within said drift space along said at least one shift direction and with a period in said shift direction corresponding to ion shift per integer number of ion reflections,
- said ion source, ion receiver, ion mirror assembly and said drift space arranged to provide a folded ion-path between said ion source and said ion receiver composed of at least one reflection by said ion mirror assembly for separating ions in time according to their mass-to-charge ratio (m/z) so that a flight time of the ions is substantially independent of ion energy.
8 more elements
Dependencies are inferred from the claim text.