Compounds and methods for delivery of prostacyclin analogs
AssigneeUnited Therapeutics Corporation
InventorsKen Phares, David Mottola
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Abstract
This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have the following formula
Claims14
An oral pharmaceutical composition comprising a compound having structure I
- wherein,
- R1 is independently selected from the group consisting of H, substituted and unsubstituted benzyl groups, and groups wherein OR1 are substituted or unsubstituted glycolamide esters;
- R2 and R3 may be the same or different and are independently selected from the group consisting of H, phosphate and groups wherein OR2 and OR3 form esters of amino acids or proteins, with the proviso that all of R1, R2 and R3 are not H;
- or enantiomers or pharmaceutically acceptable salts thereof;
- and
- and an oral excipient.
Dependencies are inferred from the claim text.