Broad spectrum cephem compounds
AssigneeShionogi & Co., Ltd.
InventorsYasuhiro Nishitani, Yoshinori Yamano
Life of this patent
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Abstract
A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene); Z+ is an optionally substituted, a cation and an N atom-containing heterocyclic group), ester, amino-protected compound wherein the amino bonds to a thiazole ring at the 7-position, or pharmaceutically acceptable salt or solvate thereof.
Claims14
A compound of the formula (I):
- a pharmaceutically acceptable salt or solvate thereof,
- wherein,
- T is S or SO;
- X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower
- alkoxy, or lower alkylthio;
- A-COOH has the formula:
- wherein R1 is hydrogen and R2 is lower alkyl;
- Z+ is a heterocyclic group having a formula selected from:
- wherein R3 and R4 are each independently selected from hydrogen, optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted lower alkenyl, optionally substituted amino, hydroxy, halogen, optionally substituted carbamoyl, optionally substituted alkyloxy, and optionally substituted heterocyclic group.
A compound of the formula (I):
- a pharmaceutically acceptable salt or solvate thereof,
- wherein,
- T is S or SO;
- X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower
- alkoxy, or lower alkylthio;
- A-COOH has the formula:
- wherein R1 is hydrogen and R2 is lower alkyl;
- and
- wherein Z+ is a heterocyclic group having a formula selected from:
- wherein R and R′ are each independently selected from hydrogen, lower alkyl, amino, mono- or di-lower alkylamino, lower alkenyl, amino lower alkyl, lower alkylamino lower alkyl, lower alkylamino lower alkylamino, amino lower alkyloxyamino, amino substitute with optionally substituted heterocyclic group, hydroxy lower alkyl, hydroxy lower alkylamino lower alkyl, lower alkoxy lower alkyl, carbamoyl lower alkyl, carboxy lower alkyl, lower alkylcarbonylamino lower alkyl, lower alkoxycarbonylamino lower alkyl, lower alkyloxy, lower alkyl having 2 kinds of substituents, and optionally substituted heterocyclic group.
A compound of the formula (I):
- a pharmaceutically acceptable salt or solvate thereof,
- wherein,
- T is S or SO;
- X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower
- alkoxy, or lower alkylthio;
- A-COOH has the formula:
- wherein R1 is hydrogen and R2 is lower alkyl;
- and
- wherein Z+ is a heterocyclic group having a formula selected from:
- wherein R is hydrogen, lower alkyl, amino lower alkyl, lower alkylamino lower alkyl, amino substituted with optionally substituted heterocyclic group, or optionally substituted heterocyclic;
- and R′ is amino.
A compound of the formula (I):
- a pharmaceutically acceptable salt or solvate thereof,
- wherein,
- T is S or SO;
- X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower
- alkoxy, or lower alkylthio;
- A-COOH has the formula:
- wherein R1 is hydrogen and R2 is lower alkyl;
- and
- wherein Z+ is a heterocyclic group having a formula selected from:
- wherein Me is methyl.
A compound of the formula (I):
- a pharmaceutically acceptable salt or solvate thereof,
- wherein,
- T is S;
- X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower
- alkoxy, or lower alkylthio;
- A-COOH has the formula:
- wherein R1 is hydrogen and R2 is methyl;
- and
- wherein
- Z+ is a heterocyclic group having a formula selected from
- wherein R and R′ are each independently selected from hydrogen, lower alkyl, amino, mono- or di-lower alkylamino, lower alkenyl, amino lower alkyl, lower alkylamino lower alkyl, lower alkylamino lower alkylamino, amino lower alkyloxyamino, amino substitute with optionally substituted heterocyclic group, hydroxy lower alkyl, hydroxy lower alkylamino lower alkyl, lower alkoxy lower alkyl, carbamoyl lower alkyl, carboxy lower alkyl, lower alkylcarbonylamino lower alkyl, lower alkoxycarbonylamino lower alkyl, lower alkyloxy, lower alkyl having 2 kinds of substituents, and optionally substituted heterocyclic group.
A compound having the following formula, or a pharmaceutically acceptable salt or a solvate thereof:
- wherein X is halogen;
- Z+ is a heterocyclic group selected from
- wherein Me is methyl.
Dependencies are inferred from the claim text.