Aligned scaffolds for improved myocardial regeneration
AssigneeSciMed Life Systems, Inc.
InventorsToby Freyman, Maria Palasis, Mark Ungs
Life of this patent
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Abstract
The present invention relates to a biocompatible, three-dimensional scaffold useful to grow cells and to regenerate or repair tissue in predetermined orientations. The scaffold is particularly useful for regeneration and repair of cardiac tissue. The scaffold contains layers of alternating A-strips and S-strips, wherein the A-strips within each layer are aligned parallel to each other and preferentially promote cellular attachment over attachment to the S-strips. Methods of producing and implanting the scaffold are also provided.
Claims29
A semi-solid, three-dimensional biocompatible scaffold for cell growth, tissue repair or regeneration comprising more than one scaffold layer of alternating attachment-strips (A-strips) and separating-strips (S-strips), wherein the A-strips within each scaffold layer are aligned parallel to each other, and wherein the A-strips preferentially promote cellular attachment to A-strips over cellular attachment to the S-strips.
A semi-solid, three-dimensional biocompatible scaffold for cell growth, tissue repair or regeneration, comprising two or more scaffold layers of alternating attachment-strips (A-strips) and separating-strips (S-strips) and one or more separating layers, wherein the A-strips comprise an extracellular matrix material, wherein the S-strips and separating layers comprise an alginate substance, and wherein the A-strips within each scaffolding layer are aligned parallel to each other and preferentially promote cellular attachment to A-strips over cellular attachment to the S-strips and the separating layers.
Dependencies are inferred from the claim text.