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US 7,381,408 B2Granted
Methods for chemically synthesizing immunoglobulin chimeric proteins
AssigneeSyntonix Pharmaceuticals, Inc.
InventorsAdam R. Mezo, Robert T. Peters
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Abstract
The invention provides methods of chemically synthesizing chimeric proteins comprising at least a portion of an immunoglobulin constant region and a biologically active molecule.
Claims26
A method of producing a chimeric protein comprising combining
- (a) at least a portion of an immunoglobulin constant region comprising an FcRn binding site and having a naturally occurring cysteine from the interchain region of the immunoglobulin as the N-terminal amino acid;
- and
- (b) a biologically active molecule comprising a functional group capable of reacting with an N terminal cysteine;
- wherein the combining of (a) and (b) produces the chimeric protein.
1 more element
A method of producing a monomer-dimer hybrid protein comprising combining
- (a) at least a portion of an immunoglobulin constant region comprising an FcRn binding site and having a naturally occurring cysteine from the interchain region of the immunoglobulin as the N-terminal amino acid;
- and
- (b) a biologically active molecule comprising a functional group capable of reacting with an N terminal cysteine;
- wherein the combining of (a) and (b) produces the monomer-dimer hybrid protein.
1 more element
Dependencies are inferred from the claim text.