Drugs for diabetes

A method of treating type 2 diabetes comprising administering to a subject a compound or salt thereof of the following formula:

• A-(B)b0-(D)c0-NO2 (I)
• wherein
• c0 is an integer and is 0 or 1;
• b0 is an integer and is 0 or 1;
• with the proviso that at least one between c0 and
• b0 is different from zero;
• A=R-T1-, wherein R-T1- is a radical or a precursor drug acetylsalicylic acid of formula R-T1-OH, wherein
• T1=(CO);
• and
• R is a remaining radical of acetylsalicylic acid;
• B=TB-X2-TBI-wherein
• TB=X, wherein X=O, S, N or NR1C, wherein R1C is H or a linear or branched alkyl having from 1 to 5 carbon atoms;
• TBI=(CO) or X, wherein X is as above defined;
• and
• X2 is a radical of a compound of formula H-X2-H selected from the following compounds:
• hydroxyacids, selected from the group consisting of:
• gallic acid, ferulic acid, gentisic acid, citric acid, caffeic acid, p-cumaric acid and vanillic acid;
• D is a bivalent radical -Tc-Y- wherein:
• when b0 is 1, Tc=(CO) when TBI=X, or Tc=X when TBI=(CO), wherein
• X is as above defined;
• when b0 is 0, Tc=X wherein X is as above defined;
• Y is:
• Yp:
• wherein:
• nIX is an integer in the range 0-3;
• nIIX is an integer in the range 1-3;
• RTIX, RTIX′, RTIIX, RTIIX′, equal to or different from each other are H or linear or branched C1-C4 alkyl,
• Y3 is a saturated, unsaturated or aromatic heterocyclic ring containing one or two nitrogen atoms, having 6 atoms;
• Y0, which is selected from the group consisting of:
• an alkylenoxy group R′ wherein R′ is C1-C20 linear or branched;
• or
• one of the following groups:
• wherein nf′ is an integer from 1 to 6;
• wherein R1f=H, CH3 and nf is an integer from 1 to 6;
• or
• YAr, which is selected from the group consisting of:
• wherein n3 is an integer from 0 to 3 and n3′ is an integer from 1 to 3;
• wherein n3 and n3′ have the above indicated meaning;
• and
• when b0=1 then c0=1 and Y is Y0;
• or
• when b0=0 then c0=1 and Y is Yp or YAr.