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US 7,375,234 B2Granted
Copper-catalysed ligation of azides and acetylenes
AssigneeThe Scripps Research Institute
InventorsK. Barry Sharpless, Valery Fokin, Vsevold A. Rostovtsev, Luke Green, Fahmi Himo
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Abstract
A metal catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to give triazoles. In many instances, the reaction sequence regiospecifically ligates azides and terminal acetylenes to give only 1,4-disubstituted [1,2,3]-triazoles.
Claims6
A Cu(I) catalyzed process for preparing a 1,4-disubstituted 1,2,3-triazole comprising:
- contacting an organic azide and a terminal alkyne with a catalytic quantity of Cu(I) ion for a time sufficient to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole.
Dependencies are inferred from the claim text.