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US 7,371,755 B1Granted
Antiviral agents
AssigneeBiota Scientific Management Pty Ltd.
InventorsGuy Krippner, Phillip A. Reece, Keith G. Watson, Wen-Yang Wu, Betty Jin, Simon P. Tucker
Life of this patent
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Abstract
This invention relates to a compound capable of binding to a picornavirus capsid comprising two or more capsid binding moieties.
Claims18
An agent for detecting rhinoviral infection in humans comprising a compound capable of binding to a rhinovirus (HRV) capsid, the compound comprising:
- at least two capsid binding moieties, and
- a non-polymeric backbone or core,
- wherein the at least two capsid binding moieties are covalently attached to the non-polymeric backbone or core,
- and wherein the at least two capsid binding moieties are the same or different and individually selected from formula (I):
- Ar1(X)mW(Y)nAr2 (I)
- where Ar1 and Ar2 are optionally substituted, aromatic mono-, bi- or tri-cyclic rings or ring systems, which may be the same or different, said aromatic rings or ring systems having 3 to 15 carbon atoms, and in the case of heteroaromatic rings, containing one or more heteroatoms selected from N, S or O;
- X and Y are independently selected from O, S, CO, C(O)O, CONR or NR, where R is hydrogen or C1-6 alkyl;
- W is selected from the group consisting of optionally substituted straight chain or branched alkylene groups of from 1 to 10 carbon atoms which may have one or more double or triple bonds;
- optionally substituted alkyleneoxy groups;
- optionally substituted aryl groups;
- and optionally substituted aliphatic rings which may be saturated or unsaturated and which may include one or more heteroatoms selected from O, S and N;
- and
- m and n are independently 0 or 1;
- said compound being linked to a detectable label.
11 more elements
Dependencies are inferred from the claim text.