Glucopyranosyloxy-substituted aromatic compounds, medicaments containing such compounds, their use and process for their manufacture

A glucopyranozyloxy-substituted aromatic compound formula (I):

• wherein
• R1 is C2-6-alkynyl, tetrahydrofuran-3-yloxy, tetrahydropyran-3-yloxy, tetrahydropyran-4-yloxy, tetrahydrofuranyl-C1-3-alkyloxy or tetrahydropyranyl-C1-3-alkyloxy, or,
• if R3 is selected from the group consisting of C2-6-alkylnyl, tetrahydrofuran-3-yloxy, tetrahydropyran-3-yloxy, tetrahydropyran-4-yloxy, tetrahydrofuranyl-C1-3-alkyloxy and tetrahydropyranyl-C1-3-alkyloxy,
• then R1 may additionally be hydrogen, fluorine, chlorine, bromine, iodine, C1-4-alkyl, a methyl group substituted by 1 to 3 fluorine atoms, an ethyl group substituted by 1 to 5 fluorine atoms, C1-4-alkoxy, a methoxy group substituted by 1 to 3 fluorine atoms, an ethoxy group substituted by 1 to 5 fluorine atoms, a C1-4-alkyl group substituted by a hydroxy or C1-3-alkoxy group, a C2-4-alkoxy group substituted by a hydroxy or C1-3-alkoxy group, C2-6-alkenyl, C3-6-cycloalkyl, C3-6-cycloalkyl-C1-3-alkyl, C3-6-cycloalkoxy, C3-6-cycloalkyl-C1-3-alkoxy, hydroxy, amino or cyano,
• R2is hydrogen, fluorine, chlorine, methyl, methyl or methoxy substituted by 1 to 3 fluorine atoms,
• R3 is C2-6-alkynyl, tetrahydrofuran-3-yloxy, tetrahydropyran-3-yloxy, tetrahydropyran-4-yloxy, tetrahydrofuranyl-C1-3-alkyloxy or tetrahydropyranyl-C1-3-alkyloxy, or,
• if R1 is selected from the group consisting of C2-6-alkynyl, tetrahydrofuran-3-yloxy, tetrahydropyran-3-yloxy, tetrahydropyran-4-yloxy, tetrahydrofuranyl-C1-3-alkyloxy and tetrahydropyranyl-C1-3-alkyloxy,
• then R3 may additionally be hydrogen, fluorine, chlorine, bromine, iodine, C1-6-alkyl, C2-6-alkenyl, C3-6-cycloalkyl, C3-6-cycloalkylidenemethyl, C1-6-alkoxy, C3-6-cycloalkyl -oxy, C3-6-cycloalkyl-C1-3-alkoxy, aryl, aryl-C1-3-alkyl, heteroaryl, heteroaryl-C1-3-alkyl, aryloxy, aryl-C1-3-alkyl-oxy, a methyl or methoxy group substituted by 1 to 3 fluorine atoms, a C2-4-alkyl or C2-4-alkoxy group substituted by 1 to 5 fluorine atoms, a C1-4-alkyl group substituted by a cyano group, a C1-4-alkyl group substituted by a hydroxy or C1-3-alkyloxy group, cyano, carboxy, C1-3-alkoxycarbonyl, aminocarbonyl, (C1-3-alkylamino)carbonyl, di-(C1-3-alkyl)aminocarbonyl, pyrrolidin-1-ylcarbonyl, piperidin-1-ylcarbonyl, morpholin-4-ylcarbonyl, piperazin-1-yl-carbonyl, 4-(C1-3-alkyl)-piperazin-1-ylcarbonyl, nitro, amino, C1-3-alkylamino, di-(C1-3-alkyl)amino, (C1-4-alkyl)carbonylamino, C1-4-alkylsulphonylamino, arylsulphonylamino, aryl-C1-4alkylsulphonylamino, C1-4-alkylsulphanyl, C1-4-alkylsulphinyl, C1-4-alkylsulphonyl, arylsulphenyl, arylsulphinyl or arylsulphonyl,
• R4 and R5, which may be identical or different, are hydrogen, fluorine, chlorine, bromine, C1-3-alkyl, C1-3-alkoxy, methyl or methoxy substituted by 1 to 3 fluorine atoms, and R6a, R7a, R7b, R7c independently of one another are hydrogen, (C1-18-alkyl)carbonyl, (C1-18-alkyl)oxycarbonyl, arylcarbonyl or aryl-(C1-3-alkyl)-carbonyl,
• while the aryl groups mentioned in the definition of the above groups are phenyl or naphthyl groups which may be mono- or disubstituted independently of one another by Rh, while the substituents may be identical or different and Rh is fluorine, chlorine, bromine, iodine, C1-3-alkyl, difluoromethyl, trifluoromethyl, C1-3-alkoxy, difluoromethoxy, trifluoromethoxy or cyano,
• the heteroaryl groups mentioned in the definition of the above-mentioned groups are a pyrrolyl, furanyl, thienyl, imidazolyl, pyridyl, indolyl, benzofuranyl, benzothiophenyl, quinolinyl or isoquinolinyl group,
• or a pyrrolyl, furanyl, thienyl, imidazolyl or pyridyl group, wherein one or two methyne groups are replaced by nitrogen atoms,
• or an indolyl, benzofuranyl, benzothiophenyl, quinolinyl or isoquinolinyl group, wherein one to three methyne groups are replaced by nitrogen atoms,
• while the above-mentioned heteroaryl groups may be mono- or disubstituted by Rh, while the substituents may be identical or different and Rh is as hereinbefore defined,
• while, unless otherwise stated, the above-mentioned alkyl groups may be straight-chain or branched,
• or a tautomer or stereoisomer thereof or mixtures thereof or a salt thereof.